Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states

JH Lee, JB Lee, Z Shapovalova… - Nature …, 2014 - nature.com
Human-induced pluripotent stem cells (hiPSCs) provide an invaluable source for
regenerative medicine, but are limited by proficient lineage-specific differentiation. Here we …

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

S Yokobayashi, Y Yabuta, M Nakagawa, K Okita… - Cell reports, 2021 - cell.com
Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to
their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well …

Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells

KH Narsinh, N Sun, V Sanchez-Freire… - The Journal of …, 2011 - Am Soc Clin Investig
Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs)
are promising candidate cell sources for regenerative medicine. However, despite the …

[HTML][HTML] Transcriptional heterogeneity in naive and primed human pluripotent stem cells at single-cell resolution

T Messmer, F von Meyenn, A Savino, F Santos… - Cell reports, 2019 - cell.com
Conventional human embryonic stem cells are considered to be primed pluripotent but can
be induced to enter a naive state. However, the transcriptional features associated with …

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

S Kilens, D Meistermann, D Moreno, C Chariau… - Nature …, 2018 - nature.com
Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental
biology and regenerative medicine, notably because they circumvent the use of cells of …

The chromatin signature of pluripotency: establishment and maintenance

DC Di Giammartino, E Apostolou - Current Stem Cell Reports, 2016 - Springer
The revolutionary discovery that somatic cells can be reprogrammed by a defined set
transcription factors to induced pluripotent stem cells (iPSCs) changed dramatically the way …

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

JM Polo, S Liu, ME Figueroa, W Kulalert, S Eminli… - Nature …, 2010 - nature.com
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …

Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells

S Ruiz, D Diep, A Gore… - Proceedings of the …, 2012 - National Acad Sciences
Generation of human induced pluripotent stem cells (hiPSCs) by the expression of specific
transcription factors depends on successful epigenetic reprogramming to a pluripotent state …

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods

JM Churko, J Lee, M Ameen, M Gu… - Nature biomedical …, 2017 - nature.com
Many reprogramming methods can generate human induced pluripotent stem cells (hiPSCs)
that closely resemble human embryonic stem cells (hESCs). This has led to assessments of …

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures

MH Chin, MJ Mason, W Xie, S Volinia, M Singer… - Cell stem cell, 2009 - cell.com
Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …