Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states
JH Lee, JB Lee, Z Shapovalova… - Nature …, 2014 - nature.com
Human-induced pluripotent stem cells (hiPSCs) provide an invaluable source for
regenerative medicine, but are limited by proficient lineage-specific differentiation. Here we …
regenerative medicine, but are limited by proficient lineage-specific differentiation. Here we …
Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells
S Yokobayashi, Y Yabuta, M Nakagawa, K Okita… - Cell reports, 2021 - cell.com
Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to
their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well …
their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well …
Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells
KH Narsinh, N Sun, V Sanchez-Freire… - The Journal of …, 2011 - Am Soc Clin Investig
Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs)
are promising candidate cell sources for regenerative medicine. However, despite the …
are promising candidate cell sources for regenerative medicine. However, despite the …
[HTML][HTML] Transcriptional heterogeneity in naive and primed human pluripotent stem cells at single-cell resolution
T Messmer, F von Meyenn, A Savino, F Santos… - Cell reports, 2019 - cell.com
Conventional human embryonic stem cells are considered to be primed pluripotent but can
be induced to enter a naive state. However, the transcriptional features associated with …
be induced to enter a naive state. However, the transcriptional features associated with …
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells
S Kilens, D Meistermann, D Moreno, C Chariau… - Nature …, 2018 - nature.com
Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental
biology and regenerative medicine, notably because they circumvent the use of cells of …
biology and regenerative medicine, notably because they circumvent the use of cells of …
The chromatin signature of pluripotency: establishment and maintenance
DC Di Giammartino, E Apostolou - Current Stem Cell Reports, 2016 - Springer
The revolutionary discovery that somatic cells can be reprogrammed by a defined set
transcription factors to induced pluripotent stem cells (iPSCs) changed dramatically the way …
transcription factors to induced pluripotent stem cells (iPSCs) changed dramatically the way …
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
JM Polo, S Liu, ME Figueroa, W Kulalert, S Eminli… - Nature …, 2010 - nature.com
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
Generation of human induced pluripotent stem cells (hiPSCs) by the expression of specific
transcription factors depends on successful epigenetic reprogramming to a pluripotent state …
transcription factors depends on successful epigenetic reprogramming to a pluripotent state …
Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods
Many reprogramming methods can generate human induced pluripotent stem cells (hiPSCs)
that closely resemble human embryonic stem cells (hESCs). This has led to assessments of …
that closely resemble human embryonic stem cells (hESCs). This has led to assessments of …
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …
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