Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation
status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

In placental mammals, balanced expression of X-linked genes is accomplished by X
chromosome inactivation (XCI) in female cells. In humans, random XCI is initiated early …

Induced pluripotent stem cells (iPSCs) acquire embryonic stem cell (ESC)-like epigenetic
states, including the X chromosome. Previous studies reported that human iPSCs retain the …

The process of X chromosome inactivation (XCI) during reprogramming to produce human
induced pluripotent stem cells (iPSCs), as well as during the extensive programming that …

Reprogramming somatic cells to derive induced pluripotent stem cells (iPSCs) has provided
a new method to model disease and holds great promise for regenerative medicine …

In mammals, X chromosome inactivation (XCI) is a process in which one of the two X
chromosomes is silenced, following XIST expression. Mouse female pluripotent stem cells …

Female human pluripotent stem cells show vast heterogeneity regarding the status of X
chromosome inactivation. By comparing the gene expression profile of cells with two active …

Acquisition of the pluripotent state coincides with epigenetic reprogramming of the X-
chromosome. Female embryonic stem cells are characterized by the presence of two active …

STUDY HYPOTHESIS Does a preferential X chromosome inactivation (XCI) pattern exist in
female human pluripotent stem cells (hPSCs) and does the pattern change during long-term …