New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions
C Taniguchi, R Inoue, M Kato, K Yamashita… - Drug Metabolism and …, 2013 - Elsevier
The aim of this study was to develop new dipyridamole (DP) salts with pH-independent
solubility for improving oral bioavailability under hypochlorhydria. Salt screening was carried …
solubility for improving oral bioavailability under hypochlorhydria. Salt screening was carried …
Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria
S Onoue, R Inoue, C Taniguchi, Y Kawabata… - International journal of …, 2012 - Elsevier
The present study aimed to develop and characterize new formulations of dipyridamole
(DP), a pH-dependent poorly soluble drug, employing an acidic pH-modifier for improving …
(DP), a pH-dependent poorly soluble drug, employing an acidic pH-modifier for improving …
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
C Taniguchi, R Inoue, Y Kawabata, K Yamashita… - International journal of …, 2012 - Elsevier
This study was undertaken to develop new dipyridamole (DP) formulations with acidic
microenvironmental pH-modifiers for improving dissolution and absorption under …
microenvironmental pH-modifiers for improving dissolution and absorption under …
Application of an in vitro dissolution/permeation system to early screening of oral formulations of poorly soluble, weakly basic drugs containing an acidic pH-modifier
M Mizoguchi, M Kataoka, K Yokoyama, R Aihara… - Journal of …, 2018 - Elsevier
This study aimed to evaluate the usefulness of the dissolution/permeation system (D/P
system) as an in vitro tool for early screening of oral formulations of weakly basic drugs …
system) as an in vitro tool for early screening of oral formulations of weakly basic drugs …
[HTML][HTML] Improved dissolution of dipyridamole with the combination of pH-modifier and solid dispersion technology
Y Kojo, S Matsunaga, H Suzuki, C Taniguchi… - Chemical and …, 2017 - jstage.jst.go.jp
The aim of this study was to develop a pH-independent release formulation of dipyridamole
(DP) by the combined use of pH-modifier technology and solid dispersion (SD) technology …
(DP) by the combined use of pH-modifier technology and solid dispersion (SD) technology …
Effect of diallyl trisulfide on the pharmacokinetics of dipyridamole in rats
Y Wang, M Zou, N Zhao, J Ren, H Zhou… - Archives of pharmacal …, 2011 - Springer
This study was aimed to evaluate the effect of diallyl trisulfide (DATS), a major component
derived from garlic used to inhibit platelet thromboxane formation, on the pharmacokinetics …
derived from garlic used to inhibit platelet thromboxane formation, on the pharmacokinetics …
Development and evaluation of dipyridamole sustained release tablets containing micro-environmental pH modifiers
Z Xi, N Sharma, A Paprikar, S Lin - Journal of Drug Delivery Science and …, 2019 - Elsevier
The objective of the present study is to develop sustained release of dipyridamole, a poorly
soluble weakly basic compound. The solubility of dipyridamole is the limit step of its …
soluble weakly basic compound. The solubility of dipyridamole is the limit step of its …
Effect of Surfactants, Gastric Emptying, and Dosage Form on Supersaturation of Dipyridamole in an in Vitro Model Simulating the Stomach and Duodenum
A Mitra, HM Fadda - Molecular pharmaceutics, 2014 - ACS Publications
The purpose of this study was to investigate the influence of gastric emptying patterns,
surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug …
surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug …
Preparation and characterization of dipyridamole solid dispersions for stabilization of supersaturation: effect of precipitation inhibitors type and molecular weight
C Vora, R Patadia, K Mittal… - Pharmaceutical …, 2016 - Taylor & Francis
Dipyridamole (DPL) is a weakly basic BCS class II drug which precipitates upon entering
into intestine leading to pH dependant and variable absorption. Thus, research envisaged …
into intestine leading to pH dependant and variable absorption. Thus, research envisaged …
Evaluation of pH-independent sustained-release granules of dipyridamole by using gastric-acidity-controlled rabbits and human subjects
N Kohri, N Miyata, M Takahashi, H Endo, K Iseki… - International journal of …, 1992 - Elsevier
The solubility of dipyridamole at pH 2.5 was about 6000-fold greater than that at pH 7.0. A
commercial powder of dipyridamole showed pH-dependent dissolution. Two kinds of …
commercial powder of dipyridamole showed pH-dependent dissolution. Two kinds of …