The orexin peptides and their two receptors are involved in multiple physiological
processes, including energy homeostasis, arousal, stress and reward. Higher signaling of …

The orexins are neuropeptides with critical functions in the central nervous system. These
neuropeptides have important roles in energy balance and obesity, and therefore on the …

The hypothalamic orexin neuropeptide acutely promotes appetite, yet orexin deficiency in
humans and mice is associated with obesity. Prolonged effects of increased orexin signaling …

Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and
sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the …

Obesity is a public health disease and its incidence is steadily increasing both in adults and
in children especially in the Western World. It is important to understand the underlying …

Obesity has increased in prevalence worldwide, attributed in part to the influences of an
obesity-promoting environment and genetic factors. While obesity and overweight …

Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein
coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2) …

The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a
cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive …

Orexin-A and-B are two peptides derived by proteolytic cleavage from a 130-amino acid
precursor, prepro-orexin, which were recently isolated from the rat hypothalamus. Orexin-A …

Orexins were initially recognized as regulators of feeding behavior due to their exclusively
production in the lateral hypothalamic area (LHA), a feeding center. Subsequently, the …