The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC)
complexes. SIN3 and its associated HDAC have been shown to have critical roles in both …

SIN3 is a component of a histone deacetylase complex known to be important for
transcription repression. While multiple isoforms of SIN3 have been reported, little is known …

Establishment and maintenance of histone acetylation levels are critical for metazoan
development and viability. Disruption of the balance between acetylation and deacetylation …

Sin3 was isolated over two decades ago as a negative regulator of transcription in budding
yeast. Subsequent research has established the protein as a master transcriptional scaffold …

The Sin3-histone deacetylase (HDAC) corepressor complex is conserved from yeast to
humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B, which …

Deacetylation of histones by the SIN3 complex is a major mechanism utilized in eukaryotic
organisms to repress transcription. Presumably, developmental and cellular phenotypes …

SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large
protein composed mainly of protein-interaction domains, whose function is to provide …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

Background The multisubunit SIN3 complex is a global transcriptional regulator. In
Drosophila, a single Sin3A gene encodes different isoforms of SIN3, of which SIN3 187 and …

The chromatin environment has a significant impact on gene expression. Chromatin
structure is highly regulated by histone modifications and RNA polymerase II binding …