At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large
protein composed mainly of protein-interaction domains, whose function is to provide …

Sin3 was isolated over two decades ago as a negative regulator of transcription in budding
yeast. Subsequent research has established the protein as a master transcriptional scaffold …

The Sin3-histone deacetylase (HDAC) corepressor complex is conserved from yeast to
humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B, which …

Acetylation is correlated with chromatin decondensation and transcriptional activation, but its
regulation by histone deacetylase (HDAC)-bearing corepressor complexes is poorly …

Silencing of gene transcription involves local chromatin modification achieved through the
local recruitment of large multiprotein complexes containing histone deacetylase (HDAC) …

The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription.
Here we describe family with sequence similarity 60A (FAM60A), a cell cycle-regulated …

The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC)
complexes. SIN3 and its associated HDAC have been shown to have critical roles in both …

The histone code is among others established via differential acetylation catalyzed by
histone acetyltransferases (HATs) and histone deacetylases (HDACs). To unambiguously …