The recruitment of chromatin-modifying coregulator complexes by transcription factors to
specific sites of the genome constitutes an important step in many eukaryotic transcriptional …

An important event in gene expression is the covalent modification of histone proteins. We
have found that the mammalian transcriptional repressor Sin3 (mSin3) exists in a complex …

Histone deacetylase 2 (HDAC2) is one of the histone-modifying enzymes that regulate gene
expression by remodeling chromatin structure. Along with HDAC1, HDAC2 is found in the …

Sin3 is an evolutionarily conserved corepressor that exists in different complexes with the
histone deacetylases HDAC1 and HDAC2. Sin3-HDAC complexes are believed to …

Histone deacetylases (HDACs) are essential catalytic components of the transcription
silencing machinery and they play important roles in the programming of multicellular …

Transcription requires the progression of RNA polymerase II (RNAP II) through a permissive
chromatin structure. Recent studies of Saccharomyces cerevisiae have demonstrated that …

Transcription repression mediated through histone deacetylase (HDAC) complexes is
widespread, and mechanisms by which HDAC complexes act have been revealed by …

The DNA in eukaryotic cells is packaged into chromatin, which functions as a boundary to
the transcriptional activation process. The nucleosome is the basic repeating unit of …

Sin3/HDAC complexes function by deacetylating histones, condensing chromatin, and
modulating gene expression. Although components used to build these complexes have …

Eukaryotic organisms from yeast to human contain a multiprotein complex that includes
Rpd3 histone deacetylase and Sin3 corepressor. The Sin3–Rpd3 complex, when recruited …