HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations
KA Swanson, PS Knoepfler, K Huang… - Nature structural & …, 2004 - nature.com
Recruitment of the histone deacetylase (HDAC)-associated Sin3 corepressor is an
obligatory step in many eukaryotic gene silencing pathways. Here we show that HBP1, a cell …
obligatory step in many eukaryotic gene silencing pathways. Here we show that HBP1, a cell …
Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex
MSM Wan, R Muhammad, MG Koliopoulos… - Nature …, 2023 - nature.com
Lysine acetylation in histone tails is a key post-translational modification that controls
transcription activation. Histone deacetylase complexes remove histone acetylation, thereby …
transcription activation. Histone deacetylase complexes remove histone acetylation, thereby …
Sin3: insight into its transcription regulatory functions
Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization
domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor …
domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor …
Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection
E Nicolas, T Yamada, HP Cam, PC FitzGerald… - Nature structural & …, 2007 - nature.com
Histone acetylation is important in regulating DNA accessibility. Multifunctional Sin3 proteins
bind histone deacetylases (HDACs) to assemble silencing complexes that selectively target …
bind histone deacetylases (HDACs) to assemble silencing complexes that selectively target …
Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor
SJ Ellison-Zelski, ET Alarid - Molecular cancer, 2010 - Springer
Background Sin3A is an evolutionarily conserved transcriptional repressor which regulates
gene expression as part of the multi-protein Sin3 repressive complex. It functions as a …
gene expression as part of the multi-protein Sin3 repressive complex. It functions as a …
CoREST is an integral component of the CoREST-human histone deacetylase complex
A You, JK Tong, CM Grozinger… - Proceedings of the …, 2001 - National Acad Sciences
Here we describe the components of a histone deacetylase (HDAC) complex that we term
the CoREST-HDAC complex. CoREST-HDAC is composed of polypeptides distinct from …
the CoREST-HDAC complex. CoREST-HDAC is composed of polypeptides distinct from …
Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity
A Sommer, S Hilfenhaus, A Menkel, E Kremmer… - Current Biology, 1997 - cell.com
Background: The organization of chromatin is crucial for the regulation of gene expression.
In particular, both the positioning and properties of nucleosomes influence promoter-specific …
In particular, both the positioning and properties of nucleosomes influence promoter-specific …
Multiple N-CoR complexes contain distinct histone deacetylases
PL Jones, LM Sachs, N Rouse, PA Wade… - Journal of Biological …, 2001 - ASBMB
N-CoR (nuclear receptor corepressor) is a corepressor for multiple transcription factors
including unliganded thyroid hormone receptors (TRs). In vitro, N-CoR can interact with the …
including unliganded thyroid hormone receptors (TRs). In vitro, N-CoR can interact with the …
The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism
LA Pile, PT Spellman, RJ Katzenberger… - Journal of Biological …, 2003 - ASBMB
Deacetylation of histones by the SIN3 complex is a major mechanism utilized in eukaryotic
organisms to repress transcription. Presumably, developmental and cellular phenotypes …
organisms to repress transcription. Presumably, developmental and cellular phenotypes …
Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo
Eukaryotic organisms contain a multiprotein complex that includes Rpd3 histone
deacetylase and the Sin3 corepressor. The Sin3-Rpd3 complex is recruited to promoters by …
deacetylase and the Sin3 corepressor. The Sin3-Rpd3 complex is recruited to promoters by …