Transcriptional silencing by many transcription factors is mediated by the nuclear
receptorcorepressor (N-CoR). The mechanism by which N-CoR represses basal …

Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl
groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is …

Histone methylation plays key roles in regulating chromatin structure and function. The
recent identification of enzymes that antagonize or remove histone methylation offers new …

We investigated the protein associations and enzymatic requirements for the Xenopus
histone deacetylase catalytic subunit RPD3 to direct transcriptional repression in Xenopus …

Histone deacetylase (HDAC) inhibitors are in clinical development for several diseases,
including cancers and neurodegenerative disorders. HDACs 1 and 2 are among the targets …

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is
known about their function in mammalian development. HDAC1 was implicated previously …

Sp1-like proteins are defined by three highly homologous C2H2 zinc finger motifs that bind
GC-rich sequences found in the promoters of a large number of genes essential for …

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression.
The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered …

Recent advances highlight two important chromatin remodeling systems involved in the
trancriptional process. One system includes several members of the evolutionarily …

Histone deacetylase 3 (HDAC3) is one of four members of the human class I histone
deacetylases that are implicated in transcriptional repression through deacetylation of …