The histone code is among others established via differential acetylation catalyzed by
histone acetyltransferases (HATs) and histone deacetylases (HDACs). To unambiguously …

Transcription in eukaryotes is governed in part by histone acetyltransferase (HAT)-and
histone deacetylase (HDAC)-containing complexes that are recruited via activators and …

HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

Repression of gene transcription is linked to regulation of chromatin structure through
deacetylation of core histone amino-terminal tails. This action is mediated by histone …

Acetylation is correlated with chromatin decondensation and transcriptional activation, but its
regulation by histone deacetylase (HDAC)-bearing corepressor complexes is poorly …

Specific recruitment of corepressor complexes containing histone deacetylases (HDAC) by
transcription factors is believed to play an essential role in transcriptional repression. Recent …

Here we describe the components of a histone deacetylase (HDAC) complex that we term
the CoREST-HDAC complex. CoREST-HDAC is composed of polypeptides distinct from …

Class IIa histone deacetylases repress transcription of target genes. However, their
mechanism of action is poorly understood because they exhibit very low levels of …

The constitutively nuclear histone deacetylases (HDACs) 1, 2, and 3 erase acetyl marks on
acetyllysine residues, alter the landscape of histone modifications, and modulate chromatin …

Histone acetylation regulates chromatin structure and gene expression and is removed by
histone deacetylases (HDACs). HDACs are commonly found in various protein complexes to …