The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription.
Here we describe family with sequence similarity 60A (FAM60A), a cell cycle-regulated …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

Sin3 is an evolutionarily conserved corepressor that exists in different complexes with the
histone deacetylases HDAC1 and HDAC2. Sin3-HDAC complexes are believed to …

Here we describe the function of a previously uncharacterized protein, named family with
sequence similarity 60 member A (FAM60A) that maps to chromosome 12p11 in humans …

SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large
protein composed mainly of protein-interaction domains, whose function is to provide …

Histone acetylation plays a key role in the regulation of eukaryotic gene expression.
Recently, histone acetylation and deacetylation were found to be catalyzed by structurally …

The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC)
complexes. SIN3 and its associated HDAC have been shown to have critical roles in both …

An important event in gene expression is the covalent modification of histone proteins. We
have found that the mammalian transcriptional repressor Sin3 (mSin3) exists in a complex …

Histone acetylation plays a key role in the regulation of gene expression. The chromatin
structure and accessibility of genes to transcription factors is regulated by enzymes that …

Histone deacetylase (HDAC) inhibition leads to cell cycle arrest in G 1 and G 2, suggesting
HDACs as therapeutic targets for cancer and diseases linked to abnormal cell growth and …