Sin3: master scaffold and transcriptional corepressor
Sin3 was isolated over two decades ago as a negative regulator of transcription in budding
yeast. Subsequent research has established the protein as a master transcriptional scaffold …
yeast. Subsequent research has established the protein as a master transcriptional scaffold …
Sin3: a flexible regulator of global gene expression and genome stability
RA Silverstein, K Ekwall - Current genetics, 2005 - Springer
SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large
protein composed mainly of protein-interaction domains, whose function is to provide …
protein composed mainly of protein-interaction domains, whose function is to provide …
Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation
G David, KB Grandinetti, PM Finnerty… - Proceedings of the …, 2008 - National Acad Sciences
The Sin3-histone deacetylase (HDAC) corepressor complex is conserved from yeast to
humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B, which …
humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B, which …
Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex
GE Adams, A Chandru, SM Cowley - Biochemical Journal, 2018 - portlandpress.com
At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …
Sin3: insight into its transcription regulatory functions
Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization
domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor …
domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor …
Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells
EF Farias, K Petrie, B Leibovitch… - Proceedings of the …, 2010 - National Acad Sciences
Sin3A/B is a master transcriptional scaffold and corepressor that plays an essential role in
the regulation of gene transcription and maintenance of chromatin structure, and its …
the regulation of gene transcription and maintenance of chromatin structure, and its …
A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci
P Jelinic, J Pellegrino, G David - Molecular and cellular biology, 2011 - Taylor & Francis
Transcription requires the progression of RNA polymerase II (RNAP II) through a permissive
chromatin structure. Recent studies of Saccharomyces cerevisiae have demonstrated that …
chromatin structure. Recent studies of Saccharomyces cerevisiae have demonstrated that …
A role for mammalian Sin3 in permanent gene silencing
The multisubunit Sin3 corepressor complex regulates gene transcription through
deacetylation of nucleosomes. However, the full range of Sin3 activities and targets is not …
deacetylation of nucleosomes. However, the full range of Sin3 activities and targets is not …
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex
L Alland, G David, H Shen-Li, J Potes… - … and cellular biology, 2002 - Taylor & Francis
Silencing of gene transcription involves local chromatin modification achieved through the
local recruitment of large multiprotein complexes containing histone deacetylase (HDAC) …
local recruitment of large multiprotein complexes containing histone deacetylase (HDAC) …
Role of the Sin3-Histone Deacetylase Complex in Growth Regulation by the Candidate Tumor Suppressor p33ING1
A Kuzmichev, Y Zhang… - … and cellular biology, 2002 - Taylor & Francis
Sin3 is an evolutionarily conserved corepressor that exists in different complexes with the
histone deacetylases HDAC1 and HDAC2. Sin3-HDAC complexes are believed to …
histone deacetylases HDAC1 and HDAC2. Sin3-HDAC complexes are believed to …