SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large
protein composed mainly of protein-interaction domains, whose function is to provide …

Sin3 was isolated over two decades ago as a negative regulator of transcription in budding
yeast. Subsequent research has established the protein as a master transcriptional scaffold …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

The Sin3-histone deacetylase (HDAC) corepressor complex is conserved from yeast to
humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B, which …

Transcription requires the progression of RNA polymerase II (RNAP II) through a permissive
chromatin structure. Recent studies of Saccharomyces cerevisiae have demonstrated that …

The multisubunit Sin3 corepressor complex regulates gene transcription through
deacetylation of nucleosomes. However, the full range of Sin3 activities and targets is not …

An important event in gene expression is the covalent modification of histone proteins. We
have found that the mammalian transcriptional repressor Sin3 (mSin3) exists in a complex …

Silencing of gene transcription involves local chromatin modification achieved through the
local recruitment of large multiprotein complexes containing histone deacetylase (HDAC) …

Sin3A/B is a master transcriptional scaffold and corepressor that plays an essential role in
the regulation of gene transcription and maintenance of chromatin structure, and its …

Deacetylation of histones by the SIN3 complex is a major mechanism utilized in eukaryotic
organisms to repress transcription. Presumably, developmental and cellular phenotypes …