Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats
C Winter, A von Rumohr, A Mundt, D Petrus… - Behavioural brain …, 2007 - Elsevier
Depression is the most common psychiatric complication in Parkinson's disease (PD). The
pathophysiological events leading to PD-associated depression, however, remain largely …
pathophysiological events leading to PD-associated depression, however, remain largely …
Partial lesion of the dopaminergic innervation of the ventral striatum induces “depressive-like” behavior of rats
K Kuter, W Kolasiewicz, K Gołembiowska… - Pharmacological …, 2011 - Springer
Depression is a frequent comorbid disorder in Parkinson's disease (PD) which may precede
appearance of its motor symptoms by several years. Pathomechanisms underlying PD have …
appearance of its motor symptoms by several years. Pathomechanisms underlying PD have …
Induction of depressive-like behavior by intranigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin
RM Santiago, J Barbiero, RW Gradowski… - Behavioural brain …, 2014 - Elsevier
Among the non-motor phenomena of Parkinson's disease (PD) are depressive symptoms,
with a prevalence of 40–70%. The reason for this high prevalence is not yet clear. The basal …
with a prevalence of 40–70%. The reason for this high prevalence is not yet clear. The basal …
Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression …
S Sugama, Y Kakinuma - Neuroscience research, 2016 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of
dopaminergic (DA) neurons in the nigrostriatal and mesolimbic pathways including ventral …
dopaminergic (DA) neurons in the nigrostriatal and mesolimbic pathways including ventral …
Temporal dissociation of striatum and prefrontal cortex uncouples anhedonia and defense behaviors relevant to depression in 6-OHDA-lesioned rats
FC Matheus, D Rial, JI Real, C Lemos… - Molecular …, 2016 - Springer
The dorsolateral striatum (DLS) processes motor and non-motor functions and undergoes
extensive dopaminergic degeneration in Parkinson's disease (PD). The nigrostriatal …
extensive dopaminergic degeneration in Parkinson's disease (PD). The nigrostriatal …
Pramipexole but not imipramine or fluoxetine reverses the “depressive-like” behaviour in a rat model of preclinical stages of Parkinson's disease
K Berghauzen-Maciejewska, K Kuter… - Behavioural brain …, 2014 - Elsevier
Depression is a frequent comorbid disorder in Parkinson's disease and may antedate its
motor symptoms. However, mechanisms underlying Parkinson's disease-associated …
motor symptoms. However, mechanisms underlying Parkinson's disease-associated …
[HTML][HTML] Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated …
RM Santiago, J Barbieiro, MMS Lima… - Progress in Neuro …, 2010 - Elsevier
Depression is a frequently encountered non-motor feature of Parkinson's disease (PD) and it
can have a significant impact on patient's quality of life. Considering the differential …
can have a significant impact on patient's quality of life. Considering the differential …
Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson's disease
Parkinson's disease (PD) involves the degeneration of dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNc) that is thought to cause the classical motor symptoms …
substantia nigra pars compacta (SNc) that is thought to cause the classical motor symptoms …
Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system
M Lee, YH Ryu, WG Cho, YW Kang, SJ Lee, TJ Jeon… - Synapse, 2015 - Wiley Online Library
Depression frequently accompanies in Parkinson's disease (PD). Previous research
suggested that dopamine (DA) and serotonin systems are closely linked with depression in …
suggested that dopamine (DA) and serotonin systems are closely linked with depression in …
Depression in Parkinson's disease: the contribution from animal studies
JL Fontoura, C Baptista, FB Pedroso… - Parkinson's …, 2017 - Wiley Online Library
Besides being better known for causing motor impairments, Parkinson's disease (PD) can
also cause many nonmotor symptoms, like depression and anxiety, which can cause …
also cause many nonmotor symptoms, like depression and anxiety, which can cause …
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