Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats

C Winter, A von Rumohr, A Mundt, D Petrus… - Behavioural brain …, 2007 - Elsevier
Depression is the most common psychiatric complication in Parkinson's disease (PD). The
pathophysiological events leading to PD-associated depression, however, remain largely …

Partial lesion of the dopaminergic innervation of the ventral striatum induces “depressive-like” behavior of rats

K Kuter, W Kolasiewicz, K Gołembiowska… - Pharmacological …, 2011 - Springer
Depression is a frequent comorbid disorder in Parkinson's disease (PD) which may precede
appearance of its motor symptoms by several years. Pathomechanisms underlying PD have …

Induction of depressive-like behavior by intranigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin

RM Santiago, J Barbiero, RW Gradowski… - Behavioural brain …, 2014 - Elsevier
Among the non-motor phenomena of Parkinson's disease (PD) are depressive symptoms,
with a prevalence of 40–70%. The reason for this high prevalence is not yet clear. The basal …

Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression …

S Sugama, Y Kakinuma - Neuroscience research, 2016 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of
dopaminergic (DA) neurons in the nigrostriatal and mesolimbic pathways including ventral …

Temporal dissociation of striatum and prefrontal cortex uncouples anhedonia and defense behaviors relevant to depression in 6-OHDA-lesioned rats

FC Matheus, D Rial, JI Real, C Lemos… - Molecular …, 2016 - Springer
The dorsolateral striatum (DLS) processes motor and non-motor functions and undergoes
extensive dopaminergic degeneration in Parkinson's disease (PD). The nigrostriatal …

Pramipexole but not imipramine or fluoxetine reverses the “depressive-like” behaviour in a rat model of preclinical stages of Parkinson's disease

K Berghauzen-Maciejewska, K Kuter… - Behavioural brain …, 2014 - Elsevier
Depression is a frequent comorbid disorder in Parkinson's disease and may antedate its
motor symptoms. However, mechanisms underlying Parkinson's disease-associated …

[HTML][HTML] Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated …

RM Santiago, J Barbieiro, MMS Lima… - Progress in Neuro …, 2010 - Elsevier
Depression is a frequently encountered non-motor feature of Parkinson's disease (PD) and it
can have a significant impact on patient's quality of life. Considering the differential …

Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson's disease

G Drui, S Carnicella, C Carcenac, M Favier… - Molecular …, 2014 - nature.com
Parkinson's disease (PD) involves the degeneration of dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNc) that is thought to cause the classical motor symptoms …

Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system

M Lee, YH Ryu, WG Cho, YW Kang, SJ Lee, TJ Jeon… - Synapse, 2015 - Wiley Online Library
Depression frequently accompanies in Parkinson's disease (PD). Previous research
suggested that dopamine (DA) and serotonin systems are closely linked with depression in …

Depression in Parkinson's disease: the contribution from animal studies

JL Fontoura, C Baptista, FB Pedroso… - Parkinson's …, 2017 - Wiley Online Library
Besides being better known for causing motor impairments, Parkinson's disease (PD) can
also cause many nonmotor symptoms, like depression and anxiety, which can cause …