ROS signalling, NADPH oxidases and cancer

WD Landry, TG Cotter - Biochemical Society transactions, 2014 - portlandpress.com
ROS (reactive oxygen species) have long been regarded as a series of destructive
molecules that have a detrimental effect on cell homoeostasis. In support of this are the …

NADPH oxidases: a perspective on reactive oxygen species production in tumor biology

JL Meitzler, S Antony, Y Wu, A Juhasz… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

Carcinogenesis and reactive oxygen species signaling: Interaction of the NADPH oxidase NOX1–5 and superoxide dismutase 1–3 signal transduction pathways

A Parascandolo, MO Laukkanen - Antioxidants & redox signaling, 2019 - liebertpub.com
Abstract Significance: Reduction/oxidation (redox) balance could be defined as an even
distribution of reduction and oxidation complementary processes and their reaction end …

Aiding and abetting roles of NOX oxidases in cellular transformation

K Block, Y Gorin - Nature Reviews Cancer, 2012 - nature.com
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts

S Coso, I Harrison, CB Harrison, A Vinh… - Antioxidants & redox …, 2012 - liebertpub.com
Significance: Reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and
peroxynitrite are generated ubiquitously by all mammalian cells and have been understood …

NADPH Oxidases NOXs and DUOXs as putative targets for cancer therapy

U Weyemi, CE Redon, PR Parekh… - Anti-Cancer Agents …, 2013 - ingentaconnect.com
Reactive oxygen species (ROS) form a class of molecules with both positive and negative
impacts on cellular health. Negatively, ROS may react with cellular constituents including …

Roles of Nox1 and other Nox isoforms in cancer development

T Kamata - Cancer science, 2009 - Wiley Online Library
The NADPH oxidase (Nox) family of enzymes generates reactive oxygen species (ROS). At
low ROS concentration, intracellular signaling is initiated, whereas at high ROS …

The ROS-NOX connection in cancer and angiogenesis

C Blanchetot, J Boonstra - Critical Reviews™ in Eukaryotic …, 2008 - dl.begellhouse.com
Initially viewed as dangerous byproducts of aerobic life, reactive oxygen species (ROS)
nowadays appear to be essential secondary messengers of many signaling cascades and …

Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets

IP Harrison, S Selemidis - Clinical and Experimental …, 2014 - Wiley Online Library
Reactive oxygen species (ROS), the cellular products of myriad physiological processes,
have long been understood to lead to cellular damage if produced in excess and to be a …

NADPH oxidases: insights into selected functions and mechanisms of action in cancer and stem cells

M Skonieczna, T Hejmo… - Oxidative Medicine …, 2017 - Wiley Online Library
NADPH oxidases (NOX) are reactive oxygen species‐(ROS‐) generating enzymes
regulating numerous redox‐dependent signaling pathways. NOX are important regulators of …