Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

Reactive oxygen species (ROS) form a class of molecules with both positive and negative
impacts on cellular health. Negatively, ROS may react with cellular constituents including …

Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

NADPH oxidases are a family of oxidases that utilize molecular oxygen to generate
hydrogen peroxide and superoxide, thus indicating physiological functions of these highly …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Dysregulated oxidative metabolism is a well-recognized aspect of cancer biology, and many
therapeutic strategies are based on targeting cancers by altering cellular redox pathways …

The NADPH oxidases (NOXs) play a recognized role in the development and progression of
inflammation-associated disorders, as well as cancer. To date, several NOX inhibitors have …

NADPH oxidases (NOX) are reactive oxygen species‐(ROS‐) generating enzymes
regulating numerous redox‐dependent signaling pathways. NOX are important regulators of …

The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …

NOX NADPH oxidases are electron-transporting membrane enzymes whose primary
function is the generation of reactive oxygen species (ROS). ROS produced by NOX …