Reactive oxygen species (ROS) form a class of molecules with both positive and negative
impacts on cellular health. Negatively, ROS may react with cellular constituents including …

Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

NADPH oxidases (NOX) are reactive oxygen species‐(ROS‐) generating enzymes
regulating numerous redox‐dependent signaling pathways. NOX are important regulators of …

Dysregulated oxidative metabolism is a well-recognized aspect of cancer biology, and many
therapeutic strategies are based on targeting cancers by altering cellular redox pathways …

NADPH oxidases are a family of oxidases that utilize molecular oxygen to generate
hydrogen peroxide and superoxide, thus indicating physiological functions of these highly …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Background: Radiotherapy is a treatment modality for cancer. For better therapeutic
efficiency, it could be used in combination with surgery, chemotherapy or immunotherapy. In …

Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

Cancer cells can survive and maintain their high proliferation rate in spite of their hypoxic
environment by deploying a variety of adaptative mechanisms, one of them being the …

The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …