RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling

S Zhuang, L Li, Y Zang, G Li… - Oncology letters, 2020 - spandidos-publications.com
Breast cancer is the second leading primary cause for cancer‑related mortality among
women and metastasis to the brain is a disastrous event for patients with increasing …

High RRM2 expression has poor prognosis in specific types of breast cancer

S Shi, Y Zhang, T Wang - PLoS One, 2022 - journals.plos.org
Background RRM2 plays an important role in different malignant tumors, but there are few
studies in breast cancer. Public databases were used to analyze the expression of RRM2 in …

Downregulated RRS1 inhibits invasion and metastasis of BT549 through RPL11‑c‑Myc‑SNAIL axis

R Wang, C Peng, J Song, Y Hua… - International …, 2022 - spandidos-publications.com
Regulator of ribosome synthesis 1 (RRS1) is a key factor in ribosome biosynthesis and other
cellular functions. High level of RRS1 in breast cancer cell lines is associated with increased …

Overexpression of RRM2 in gastric cancer cell promotes their invasiveness via AKT/NF-kB signaling pathway

Z Zhong, Y Cao, S Yang… - Die Pharmazie-An …, 2016 - ingentaconnect.com
The ribonucleotide reductase M2 subunit (RRM2) plays an active role in tumor progression
and is frequently overexpressed in cancer. It plays a significant role in the regulation of cell …

RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance

MA Abdel-Rahman, M Mahfouz, HO Habashy - Diagnostic Pathology, 2022 - Springer
Background Breast cancer is one of the most common types of cancer. Ribonucleotide
reductase (RNR) is a heterodimeric tetramer consisting of two Ribonucleoside-diphosphate …

RRM2 promotes the progression of human glioblastoma

C Li, J Zheng, S Chen, B Huang, G Li… - Journal of cellular …, 2018 - Wiley Online Library
Glioblastoma pathogenesis is related to multiple processes that affected by dozens of
regulatory factors, but the potential underlying factors regulating glioblastoma progression …

Bioinformatics analysis revealing prognostic significance of RRM2 gene in breast cancer

W Chen, L Yang, L Xu, L Cheng, Q Qian… - Bioscience …, 2019 - portlandpress.com
Background: Ribonucleotide reductase M2 subunit (RRM2) plays vital roles in many cellular
processes such as cell proliferation, invasiveness, migration, angiogenesis, senescence …

RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression

P Chen, X Yue, H Xiong, X Lu… - … Journal of Oncology, 2019 - spandidos-publications.com
Breast cancer is one of the most common types of cancers which results in a high mortality
rate for patients worldwide. In this study, we performed systematical experiments including …

RRM1 is mediated by histone acetylation through gemcitabine resistance and contributes to invasiveness and ECM remodeling in pancreatic cancer

H Ono, Y Murase, H Yamashita… - International …, 2023 - spandidos-publications.com
The invasiveness of pancreatic cancer and its resistance to anticancer drugs define its
malignant potential, and are considered to affect the peritumoral microenvironment. Cancer …

PRRX2 as a novel TGF‐β‐induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer

YL Juang, YM Jeng, CL Chen… - Molecular …, 2016 - Wiley Online Library
TGF‐β and cancer progression share a multifaceted relationship. Despite the knowledge of
TGF‐β biology in the development of cancer, several factors that mediate the cancer …