Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of
white adipose tissue in mice. Despite their morphological similarities to brown adipocytes …

Physiological, pharmacological and genetic studies in dogs, mice and rats have established
that the uncoupling protein-1 (UCP1)-based brown adipose tissue system has an important …

Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

Investigations of variations in metabolic efficiency and thermogenesis have a short and
turbulent history. In small animals, non‐shivering thermogenesis and diet‐induced …

Only with the development of the uncoupling protein 1 (UCP1)-ablated mouse has it become
possible to strictly delineate the physiological significance of the thermogenic capacity of …

The issue under discussion here is whether a decrease in the degree of UCP1 activity (and
brown adipose tissue activity in general) could be a cause of obesity in humans. This …

Regulated transcription of the uncoupling protein-1 (UCP1) gene, and subsequent UCP1
protein synthesis, is a hallmark of the acquisition of the differentiated, thermogenically …

Adaptive nonshivering thermogenesis may have profound effects on energy balance and is
therefore therefore is a potential mechanism for counteracting the development of obesity …

We have identified a novel cDNA encoding a protein highly homologous to the mammalian
brown fat uncoupling protein (UCP). Unlike the known UCP, which is expressed specifically …

Brown adipose tissue is uniquely able to rapidly produce large amounts of heat through
activation of uncoupling protein (UCP) 1. Maximally stimulated brown fat can produce 300 …