A dopaminergic deficiency in patients with Parkinson's disease (PD) causes abnormalities of
movement, behaviour, learning, and emotions. The main motor features (ie, tremor, rigidity …

The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Several studies, including work from the Parkinson's disease (PD) non-motor group and
others, have established that the non-motor symptoms of PD are common, occur across all …

Reviews current information on Parkinson's disease. Brain lesions; Lesions and symptoms;
Rate of degeneration of dopaminergic neurons; Death of dopaminergic neurons; Genetic …

Cognitive impairment in patients with Parkinson's disease is gaining increased clinical
significance owing to the relative success of therapeutic approaches to the motor symptoms …

The correct diagnosis of Parkinson's disease is important for prognostic and therapeutic
reasons and is essential for clinical research. Investigations of the diagnostic accuracy for …

Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been characterised by the classical motor features of parkinsonism associated with Lewy …

Neuromodulatory or even neuroprotective therapy could soon be available for Parkinson's
disease (PD), raising the question of how we should define and measure disease …

Parkinson's disease is the most common serious movement disorder in the world, affecting
about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons …

The motor symptoms of Parkinson's disease are predominantly due to progressive
degeneration of nigral dopaminergic neurons. In most cases there is a substantial …