The human uncoupling protein‐1 gene (UCP1): present status and perspectives in obesity research
MDM Gonzalez‐Barroso, D Ricquier… - Obesity …, 2000 - Wiley Online Library
Energy expenditure through brown adipose tissue thermogenesis contributes either to
maintenance of body temperature in a cold environment or to wasted food energy, ie cold …
maintenance of body temperature in a cold environment or to wasted food energy, ie cold …
Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
Mitochondrial uncoupling proteins (UCPs) are transporters that are important for
thermogenesis. The net result of their activity is the exothermic movement of protons through …
thermogenesis. The net result of their activity is the exothermic movement of protons through …
The role of uncoupling proteins in the regulation of metabolism
C Erlanson‐Albertsson - Acta Physiologica Scandinavica, 2003 - Wiley Online Library
Investigations of variations in metabolic efficiency and thermogenesis have a short and
turbulent history. In small animals, non‐shivering thermogenesis and diet‐induced …
turbulent history. In small animals, non‐shivering thermogenesis and diet‐induced …
Uncoupling protein 1 expression and high-fat diets
T Fromme, M Klingenspor - American Journal of Physiology …, 2011 - journals.physiology.org
Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled
nonshivering thermogenesis in brown adipocytes. This process combusts stored and …
nonshivering thermogenesis in brown adipocytes. This process combusts stored and …
The effect of mild cold exposure on UCP3 mRNA expression and UCP3 protein content in humans
P Schrauwen, MS Westerterp-Plantenga… - International journal of …, 2002 - nature.com
OBJECTIVE: In rodents, adaptive thermogenesis in response to cold exposure and high-fat
feeding is accomplished by the activation of the brown adipose tissue specific mitochondrial …
feeding is accomplished by the activation of the brown adipose tissue specific mitochondrial …
Human uncoupling protein‐3 and obesity: an update
MKC Hesselink, M Mensink, P Schrauwen - Obesity research, 2003 - Wiley Online Library
The cloning of the uncoupling protein (UCP) 1 homologs UCP2 and UCP3 has raised
considerable interest in the mechanism. The expression of UCP3 mainly in skeletal muscle …
considerable interest in the mechanism. The expression of UCP3 mainly in skeletal muscle …
Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue
Abstract Uncoupling protein 2 (UCP2) was discovered in 1997 and classified as an
uncoupling protein largely based on its homology of sequence with UCP1. Since its …
uncoupling protein largely based on its homology of sequence with UCP1. Since its …
Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects
L Nordfors, J Hoffstedt, B Nyberg, A Thörne, P Arner… - Diabetologia, 1998 - Springer
Massive overweight is an increasing health problem and underlies several complications
which in turn result in premature death. The mechanisms underlying the imbalance between …
which in turn result in premature death. The mechanisms underlying the imbalance between …
Invited review: uncoupling proteins and thermoregulation
G Argyropoulos, ME Harper - Journal of applied physiology, 2002 - journals.physiology.org
Energy balance in animals is a metabolic state that exists when total body energy
expenditure equals dietary energy intake. Energy expenditure, or thermogenesis, can be …
expenditure equals dietary energy intake. Energy expenditure, or thermogenesis, can be …
Increased uncoupling protein-2 and-3 mRNA expression during fasting in obese and lean humans.
L Millet, H Vidal, F Andreelli, D Larrouy… - The Journal of …, 1997 - Am Soc Clin Investig
Uncoupling protein-2 and-3 (UCP2 and UCP3) are mitochondrial proteins that show high
sequence homology with the brown adipocyte-specific UCP1. UCP1 induces heat …
sequence homology with the brown adipocyte-specific UCP1. UCP1 induces heat …