[HTML][HTML] UCP1 in adipose tissues: two steps to full browning
AV Kalinovich, JMA de Jong, B Cannon, J Nedergaard - Biochimie, 2017 - Elsevier
The possibility that brown adipose tissue thermogenesis can be recruited in order to combat
the development of obesity has led to a high interest in the identification of “browning …
the development of obesity has led to a high interest in the identification of “browning …
UCP1 mRNA does not produce heat
J Nedergaard, B Cannon - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
Because of the possible role of brown adipose tissue and UCP1 in metabolic regulation,
even in adult humans, there is presently considerable interest in quantifying, from in-vitro …
even in adult humans, there is presently considerable interest in quantifying, from in-vitro …
The browning of white adipose tissue: some burning issues
J Nedergaard, B Cannon - Cell metabolism, 2014 - cell.com
Igniting thermogenesis within white adipose tissue (ie, promoting expression and activity of
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …
UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/-mice
J Ukropec, RP Anunciado, Y Ravussin… - Journal of Biological …, 2006 - ASBMB
Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of
thermogenic mechanisms that can be activated to reduce a positive energy balance is …
thermogenic mechanisms that can be activated to reduce a positive energy balance is …
[HTML][HTML] UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
IG Shabalina, N Petrovic, JMA de Jong, AV Kalinovich… - Cell reports, 2013 - cell.com
The phenomenon of white fat" browning," in which certain white adipose tissue depots
significantly increase gene expression for the uncoupling protein UCP1 and thus …
significantly increase gene expression for the uncoupling protein UCP1 and thus …
Brown adipose tissue: can it keep us slim? A discussion of the evidence for and against the existence of diet-induced thermogenesis in mice and men
J Nedergaard, G von Essen… - … Transactions of the …, 2023 - royalsocietypublishing.org
The issue under discussion here is whether a decrease in the degree of UCP1 activity (and
brown adipose tissue activity in general) could be a cause of obesity in humans. This …
brown adipose tissue activity in general) could be a cause of obesity in humans. This …
Thermogenic responses in brown fat cells are fully UCP1-dependent: UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced thermogenesis
A Matthias, KBE Ohlson, JM Fredriksson… - Journal of Biological …, 2000 - ASBMB
To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the
thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was …
thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was …
Uncoupling protein 1 expression and high-fat diets
T Fromme, M Klingenspor - American Journal of Physiology …, 2011 - journals.physiology.org
Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled
nonshivering thermogenesis in brown adipocytes. This process combusts stored and …
nonshivering thermogenesis in brown adipocytes. This process combusts stored and …
A reservoir of brown adipocyte progenitors in human skeletal muscle
M Crisan, L Casteilla, L Lehr, M Carmona… - Stem …, 2008 - academic.oup.com
Brown adipose tissue uncoupling protein-1 (UCP1) plays a major role in the control of
energy balance in rodents. It has long been thought, however, that there is no …
energy balance in rodents. It has long been thought, however, that there is no …
Brown adipose tissue growth and development
ME Symonds - Scientifica, 2013 - Wiley Online Library
Brown adipose tissue is uniquely able to rapidly produce large amounts of heat through
activation of uncoupling protein (UCP) 1. Maximally stimulated brown fat can produce 300 …
activation of uncoupling protein (UCP) 1. Maximally stimulated brown fat can produce 300 …