Substantia Nigra Dopamine Neuronal Responses to Habenular Stimulation and Foot Shock Are Altered by Lesions of the Rostromedial Tegmental Nucleus

PL Brown, H Palacorolla, DE Cobb-Lewis, TC Jhou… - Neuroscience, 2024 - Elsevier
Dopamine (DA) neurons of the substantia nigra (SN) and ventral tegmental area generally
respond to aversive stimuli or the absence of expected rewards with transient inhibition of …

Habenula-induced inhibition of midbrain dopamine neurons is diminished by lesions of the rostromedial tegmental nucleus

PL Brown, H Palacorolla, D Brady… - Journal of …, 2017 - Soc Neuroscience
Neurons in the lateral habenula (LHb) are transiently activated by aversive events and have
been implicated in associative learning. Functional changes associated with tonic and …

Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates

S Hong, TC Jhou, M Smith, KS Saleem… - Journal of …, 2011 - Soc Neuroscience
Lateral habenula (LHb) neurons signal negative “reward-prediction errors” and inhibit
midbrain dopamine (DA) neurons. Yet LHb neurons are largely glutamatergic, indicating that …

Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons

X Shen, X Ruan, H Zhao - PloS one, 2012 - journals.plos.org
Ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc) are midbrain
structures known to be involved in mediating reward in rodents. Lateral habenula (LHb) is …

The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental …

JJ Balcita‐Pedicino, N Omelchenko… - Journal of …, 2011 - Wiley Online Library
The lateral habenula (LHb) provides an important source of negative reinforcement signals
to midbrain dopamine (DA) cells in the substantia nigra and ventral tegmental area (VTA) …

Lesions of the fasciculus retroflexus alter footshock-induced cFos expression in the mesopontine rostromedial tegmental area of rats

PL Brown, PD Shepard - PLoS One, 2013 - journals.plos.org
Midbrain dopamine neurons are an essential part of the circuitry underlying motivation and
reinforcement. They are activated by rewards or reward-predicting cues and inhibited by …

[HTML][HTML] The rostromedial tegmental nucleus (RMTg), a major GABAergic afferent to midbrain dopamine neurons, selectively encodes aversive stimuli and promotes …

TC Jhou, HL Fields, MG Baxter, CB Saper, PC Holland - Neuron, 2009 - ncbi.nlm.nih.gov
Separate studies have implicated the lateral habenula (LHb) or amygdala-related regions in
processing aversive stimuli, but their relationships to each other and to appetitive …

The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses

TC Jhou, HL Fields, MG Baxter, CB Saper, PC Holland - Neuron, 2009 - cell.com
Separate studies have implicated the lateral habenula (LHb) or amygdala-related regions in
processing aversive stimuli, but their relationships to each other and to appetitive …

Rostromedial tegmental nucleus-substantia nigra pars compacta circuit mediates aversive and despair behavior in mice

Y Sun, J Cao, C Xu, X Liu, Z Wang, H Zhao - Experimental Neurology, 2020 - Elsevier
GABAergic neurons in the rostromedial tegmental nucleus (RMTg) receive major input from
the lateral habenula (LHb), which conveys negative reward and motivation related …

A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward

AM Stamatakis, JH Jennings, RL Ung, GA Blair… - Neuron, 2013 - cell.com
Lateral habenula (LHb) neurons convey aversive and negative reward conditions through
potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although …