Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Cytokines are soluble mediators, which aid cell-to-cell communication in immune
responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and …

Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …

Abstract Interleukin-6 (IL-6) is a cytokine with redundant and pleiotropic activities, and its
synthesis is tightly regulated by transcriptional and posttranscriptional mechanisms. When …

Background: IL-6, a glycoprotein composed of 212 amino acids in human, has a wide range
of biological activity, including regulation of immune response, support of hematopoiesis …

Interleukin (IL)-6 contributes to a myriad of physiologic and pathophysiologic processes.
Among its many physiologic functions, IL-6 plays an active role in immunology, inflammatory …

Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …

Abstract Interleukin-6 (IL-6) is a pro-inflammatory cytokine involved in the pathogenesis of
various autoimmune and chronic inflammatory diseases. Binding of IL-6 to its receptor (IL …

Interleukin 6 (IL-6), a well-known pro-inflammatory cytokine with pleiotropic activity is a
central player in chronic inflammatory diseases including cancers. Therefore, blockade of …

Introduction: Rheumatoid arthritis (RA) is an autoimmune chronic disease with joint and
systemic inflammation and it has been found that interleukin-6 (IL-6) plays a key role in RA …