Interleukin 6: from bench to bedside

N Nishimoto, T Kishimoto - Nature clinical practice Rheumatology, 2006 - nature.com
Abstract Interleukin (IL)-6 is a pleiotropic cytokine that has important roles in the regulation of
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …

Interleukin-6: from an inflammatory marker to a target for inflammatory diseases

M Rincon - Trends in immunology, 2012 - cell.com
The incidence and diversity of chronic inflammatory diseases is increasing worldwide.
However, the complexity of clinical symptoms has made it difficult to develop therapies that …

Interleukin (IL-6) immunotherapy

T Tanaka, M Narazaki… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …

Interleukin-6: from identification of the cytokine to development of targeted treatments

E Assier, MC Boissier, JM Dayer - Joint Bone Spine, 2010 - Elsevier
Interleukin-6 (IL-6) was identified based on extensive research conducted simultaneously on
a variety of topics ranging from hepatocyte production of acute-phase proteins to …

[HTML][HTML] Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases

T Tanaka, T Kishimoto - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

K Ishihara, T Hirano - Cytokine & growth factor reviews, 2002 - Elsevier
Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now
known to be a multifunctional cytokine that regulates the immune response, hematopoiesis …

Interleukin 6 and rheumatoid arthritis

Y Yoshida, T Tanaka - BioMed research international, 2014 - Wiley Online Library
Interleukin‐6 (IL‐6) is a representative cytokine featuring pleiotropic activity and
redundancy. A transient synthesis of IL‐6 contributes to host defense against infectious …

IL-6 as a keystone cytokine in health and disease

CA Hunter, SA Jones - Nature immunology, 2015 - nature.com
Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

The biology behind interleukin-6 targeted interventions

X Liu, GW Jones, EH Choy… - Current opinion in …, 2016 - journals.lww.com
The biology behind interleukin-6 targeted interventions : Current Opinion in Rheumatology The
biology behind interleukin-6 targeted interventions : Current Opinion in Rheumatology Log in or …

A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

T Tanaka, M Narazaki, A Ogata, T Kishimoto - Seminars in immunology, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a cytokine with redundant and pleiotropic activities, and its
synthesis is tightly regulated by transcriptional and posttranscriptional mechanisms. When …