Metastatic bone disease is a common manifestation of advanced disease in patients with the
most frequent malignancies such as breast cancer, prostate cancer, and lung cancer. Eighty …

Metastasis to the bone represents a frequent complication of visceral cancers, most
commonly in patients with advanced breast, prostate, and lung cancer. More than 50% of …

The most commonly diagnosed tumor in the skeleton represents metastatic disease.
Metastatic carcinoma should be the first consideration in older patients with atypical …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

Bone metastases are common complications of many cancers. Among the mechanisms that
set the scene for the development of bone metastases, several are shared by all forms of …

Bone is the third most frequent site of tumor metastasis; it is estimated that in the United
States approximately 350,000 people die each year from bone metastases [1]. Analysis of …

A pathological fracture occurs through an area of abnormal bone. There is either a reduction
in the quantity or quality of bone present. Bone metastases from visceral primary lesions or …

Metastases in bone are common, yet malignant tumours rarely arise in the skeleton. Primary
cancers in other tissues, notably the breast and colon, are common but seldom do …