Metastases in bone are common, yet malignant tumours rarely arise in the skeleton. Primary
cancers in other tissues, notably the breast and colon, are common but seldom do …

Bone is the second most common site of metastases in human cancer. At least two-thirds of
the approximately 553,400 Americans who die from cancer each year have bone …

Bone Metastases brings together the many recent developments that are gradually
improving the prospects for patients with secondary involvement of the skeleton in a primary …

e13099 Background: Solid tumors frequently metastasize to bone, which can lead to serious
bone complications. Population-based estimates of bone metastasis incidence are limited …

Bone involvement with cancer frequently occurs and is the third most common site for cancer
metastasis. Bone is only exceeded by lung, liver, and lymph nodes as a metastatic site for …

Metastatic bone disease is common, and affects more than 5 million individuals in the United
States. Patients may present with bone pain. If a patient is known to have a cancer that …

The treatment of metastatic disease remains challenging. The number of patients who will
be diagnosed with metastatic bone disease will continue to increase as survival from the …

Cancer adversely affects bone and mineral metabolism through a broad spectrum of
mechanisms. These include focal osteolysis at sites of metastases, hypercalcemia, and …