Rationale: The dual challenges to tuberculosis (TB) control of HIV infection and multidrug
resistance are particularly pressing in South Africa. Conventional methods for detecting …

Background Drug-resistant tuberculosis continues to be a global public health threat.
Ethiopia is one of the high-burden countries for tuberculosis and multi-drug resistant …

Background The aim of this study was to compare the performance of several recently
developed assays for the detection of multi-and extensively drug-resistant tuberculosis …

Background Accurate and rapid tests for tuberculosis (TB) drug resistance are critical for
improving patient care and decreasing the transmission of drug‐resistant TB. Genotype® …

Summary Background The Xpert MTB/RIF test (Cepheid, Sunnyvale, CA, USA) can detect
tuberculosis and its multidrug-resistant form with very high sensitivity and specificity in …

Background The dual challenge of low diagnostic sensitivity of microscopy test and technical
challenge of performing a TB culture test poses a problem for case detection and initiation of …

Background Tuberculosis is a leading cause of infectious disease‐related death and is one
of the top 10 causes of death worldwide. The World Health Organization (WHO) …

Background An algorithm instituted following Xpert MTB/RIF (Xpert) introduction in South
Africa advocates for treating all Xpert rifampicin resistant patients as MDR-TB cases while …

Global TB control efforts have been severely hampered by the lack of diagnostic tests that
are accurate, simple to use and can be applied at the point of clinical care. This has been …

If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future,
improved detection of patients, earlier diagnosis and timely identification of rifampicin …