Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope

EC Tapley, DA Starr - Current opinion in cell biology, 2013 - Elsevier
The nuclear–cytoskeleton connection influences many aspects of cellular architecture,
including nuclear positioning, the stiffness of the global cytoskeleton, and …

[HTML][HTML] LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins

BA Sosa, A Rothballer, U Kutay, TU Schwartz - Cell, 2012 - cell.com
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope
and are composed of KASH and SUN proteins residing in the outer and inner nuclear …

[HTML][HTML] The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin

A Rothballer, U Kutay - Chromosoma, 2013 - Springer
The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by
linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from …

Making the LINC: SUN and KASH protein interactions

DI Kim, B KC, KJ Roux - Biological Chemistry, 2015 - degruyter.com
Cell nuclei are physically integrated with the cytoskeleton through the linker of
nucleoskeleton and cytoskeleton (LINC) complex, a structure that spans the nuclear …

Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections

D Razafsky, D Hodzic - Journal of Cell Biology, 2009 - rupress.org
The nucleus is the most prominent cellular organelle, and its sharp boundaries suggest the
compartmentalization of the nucleoplasm from the cytoplasm. However, the recent …

[HTML][HTML] Structural insights into SUN-KASH complexes across the nuclear envelope

W Wang, Z Shi, S Jiao, C Chen, H Wang, G Liu… - Cell research, 2012 - nature.com
Linker of the nucleoskeleton and the cytoskeleton (LINC) complexes are composed of SUN
and KASH domain-containing proteins and bridge the inner and outer membranes of the …

SUN/KASH interactions facilitate force transmission across the nuclear envelope

H Hao, DA Starr - Nucleus, 2019 - Taylor & Francis
ABSTRACT LINC complexes (Linker of Nucleoskeleton and Cytoskeleton), consisting of
inner nuclear membrane SUN (Sad1, UNC-84) proteins and outer nuclear membrane KASH …

Molecular models of LINC complex assembly at the nuclear envelope

Z Jahed, N Domkam, J Ornowski… - Journal of Cell …, 2021 - journals.biologists.com
Large protein complexes assemble at the nuclear envelope to transmit mechanical signals
between the cytoskeleton and nucleoskeleton. These protein complexes are known as the …

[HTML][HTML] Conserved SUN-KASH interfaces mediate LINC complex-dependent nuclear movement and positioning

NE Cain, Z Jahed, A Schoenhofen, VA Valdez, B Elkin… - Current Biology, 2018 - cell.com
Many nuclear positioning events involve linker of nucleoskeleton and cytoskeleton (LINC)
complexes, which transmit forces generated by the cytoskeleton across the nuclear …

Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges

DA Starr, HN Fridolfsson - Annual review of cell and …, 2010 - annualreviews.org
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …