The melanocortin 1 receptor gene is a main determinant of human pigmentation, and a
melanoma susceptibility gene, because its variants that are strongly associated with red hair …

Beginning in the last decade of the twentieth century, the fields of pigment cell research and
melanoma have witnessed major breakthroughs in the understanding of the role of …

Cutaneous pigmentation is the major photoprotective mechanism against the carcinogenic
and aging effects of UV. Epidermal melanocytes synthesize the pigment melanin, in the form …

Cutaneous pigmentation is determined by the amounts of eumelanin and pheomelanin
synthesized by epidermal melanocytes and is known to protect against sun-induced DNA …

The significance of human cutaneous pigmentation lies in its protective role against sun‐
induced DNA damage and photocarcinogenesis. Fair skin and red hair are characterized by …

The melanocortin MC1 receptor is a G-protein coupled receptor expressed in the
melanocytes of the skin and hair and is known for its key role in the regulation of human …

The melanocortin 1 receptor gene (MC1R), a well-established melanoma susceptibility
gene, regulates the amount and type of melanin pigments formed within epidermal …

The melanocortin‐1 receptor (MC1R) is a key gene involved in the regulation of melanin
synthesis and encodes a G‐protein coupled receptor expressed on the surface of the …

Abstract Melanocortin‐1 Receptor (MC1R), when stimulated by alpha‐melanocyte‐
stimulating hormone (α‐MSH), is a driver of eumelanogenesis. Brown/black eumelanin is an …

The membrane bound melanocortin 1 receptor (MC1R), and the endothelin B receptor
(ENDBR) are two G-protein coupled receptors that play important roles in constitutive …