Mechanisms governing inflammasome activation, assembly and pyroptosis induction
S Kesavardhana, TD Kanneganti - International Immunology, 2017 - academic.oup.com
Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …
Mechanistic insights from inflammasome structures
Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …
pathogen-associated and damage-associated stimuli, as well as other danger signals that …
Regulation of inflammasome activation
SM Man, TD Kanneganti - Immunological reviews, 2015 - Wiley Online Library
Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …
Over the past 10 years, inflammasomes have been recognized for their roles in the host …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
Mechanisms of inflammasome activation: recent advances and novel insights
SK Vanaja, VAK Rathinam, KA Fitzgerald - Trends in cell biology, 2015 - cell.com
Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …
Inflammasome activation and assembly at a glance
A Malik, TD Kanneganti - Journal of cell science, 2017 - journals.biologists.com
Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …
Mechanisms and consequences of noncanonical inflammasome-mediated pyroptosis
SS Wright, SO Vasudevan, VA Rathinam - Journal of molecular biology, 2022 - Elsevier
The noncanonical inflammasome, comprising inflammatory caspases 4, 5, or 11, monitors
the cytosol for bacterial lipopolysaccharide (LPS). Intracellular LPS-elicited autoproteolysis …
the cytosol for bacterial lipopolysaccharide (LPS). Intracellular LPS-elicited autoproteolysis …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
Structural mechanisms of inflammasome assembly
Inflammasomes are supramolecular signaling complexes that activate a subset of caspases
known as the inflammatory caspases, an example of which is caspase 1. Upon stimulation …
known as the inflammatory caspases, an example of which is caspase 1. Upon stimulation …