Peptide agonists and antagonists with potential application in neurological disorders

A Russo, SL Manna, G Morelli… - Recent Patents on …, 2015 - ingentaconnect.com
Background: Peptides are usually used to investigate regulatory networks and protein
function. They can also be used in therapeutic research: They are employed both to identify …

Editorial (Thematic Issue: Peptides as a Novel Therapeutic Approach for Neurodegenerative Diseases)

Z Khan - Current Medicinal Chemistry, 2014 - ingentaconnect.com
Peptides and proteins are the natural means of activating and inhibiting cellular
mechanisms. Normal functions of the central nervous system (CNS) largely dependent on …

Peptides: important tools for the treatment of central nervous system disorders

L Malavolta, FR Cabral - Neuropeptides, 2011 - Elsevier
This review shows some classical applications of peptides and suggests there is great
promise for the treatment of various central nervous system diseases. Actually, peptides are …

Peptide based therapy for neurological disorders

A Yadav, D Pandey, GM Ashraf - Current Protein and Peptide …, 2021 - ingentaconnect.com
Peptides are small molecules composed of amino acids linked together by peptide bonds.
The targeted action of these peptides along with their magnificent ability to reach locations in …

Whether short peptides are good candidates for future neuroprotective therapeutics?

R Perlikowska - Peptides, 2021 - Elsevier
Neurodegenerative diseases are a broad group of largely debilitating, and ultimately
terminal conditions resulting in progressive degeneration of different brain regions. The …

Peptide Drugs: Current Status and it's Applications in the Treatment of Various Diseases

C Chandarana, I Juwarwala, S Shetty… - Current Drug Research …, 2024 - ingentaconnect.com
Peptides represent a class of natural molecules with diverse physiological functions,
including hormone regulation, neurotransmission, and immune modulation. In recent years …

Potentials of neuropeptides as therapeutic agents for neurological diseases

XY Yeo, G Cunliffe, RC Ho, SS Lee, S Jung - Biomedicines, 2022 - mdpi.com
Despite recent leaps in modern medicine, progress in the treatment of neurological diseases
remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of …

Concepts for biologically active peptides

AJ Kastin, W Pan - Current pharmaceutical design, 2010 - ingentaconnect.com
Here we review a unique aspect of CNS research on biologically active peptides that started
against a background of prevalent dogmas but ended by exerting considerable influence on …

Peptides as receptor ligand drugs and their relationship to G-coupled signal transduction

GJ Mizejewski - Expert Opinion on Investigational Drugs, 2001 - Taylor & Francis
Peptides act as effector agents that regulate and/or mediate physiological processes,
serving as hormones, neurotransmitters and signal transducing factors. The low molecular …

Peptide therapeutics for CNS indications

P McGonigle - Biochemical Pharmacology, 2012 - Elsevier
Neuropeptides play a crucial role in the normal function of the central nervous system and
peptide receptors hold great promise as therapeutic targets for the treatment of several CNS …