Background Hemodynamic overload causes cardiac hypertrophy leading to heart failure.
Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related …

Background In animal models, secreted frizzled related protein 1 (Sfrp1) inhibition of the Wnt
signaling pathway is beneficial because Sfrp1 reduces myocardial apoptosis and prevents …

Background and aim Secreted frizzled-related protein 2 (sFRP2) has been reported to be
involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by …

Wnt signaling has diverse actions in cardiovascular development and disease processes.
Secreted frizzled-related protein 5 (Sfrp5) has been shown to function as an extracellular …

Background—The Wnt/β-catenin signaling pathway plays a central role during cardiac
development and has been implicated in cardiac remodeling and aging. However, the role …

The Wnt signaling pathway plays important roles in organ development and disease
processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling …

Progressive cardiac fibrosis accelerates the development of heart failure. Here, we aimed to
explore serum Wnt5a and Wnt11 levels in hypertension patients, the roles of Wnt5a and …

Background Lately, there is accumulating evidence that the Wnt/Frizzled pathway is
reactivated after myocardial infarction, the inhibition of the pathway is beneficial since it …

Postinfarct cardiac hypertrophy is an independent risk factor for heart failure and sudden
death. Regression of cardiac hypertrophy has emerged as a promising strategy in the …

We have demonstrated that mesenchymal stem cells overexpressing the survival gene Akt
can confer paracrine protection to ischemic myocytes both in vivo and in vitro through the …