Sfrp1 attenuates TAC-induced cardiac dysfunction by inhibiting Wnt signaling pathway-mediated myocardial apoptosis in mice
S Pan, X Zhao, X Wang, X Tian, Y Wang, R Fan… - Lipids in Health and …, 2018 - Springer
Background Hemodynamic overload causes cardiac hypertrophy leading to heart failure.
Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related …
Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related …
Secreted frizzled related protein 1 protects H9C2 cells from hypoxia/re-oxygenation injury by blocking the Wnt signaling pathway
J Tao, M Abudoukelimu, Y Ma, Y Yang, X Li… - Lipids in health and …, 2016 - Springer
Background In animal models, secreted frizzled related protein 1 (Sfrp1) inhibition of the Wnt
signaling pathway is beneficial because Sfrp1 reduces myocardial apoptosis and prevents …
signaling pathway is beneficial because Sfrp1 reduces myocardial apoptosis and prevents …
Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway
WY Wei, Q Zhao, W Zhang, M Wang, Y Li… - Molecular and Cellular …, 2020 - Springer
Background and aim Secreted frizzled-related protein 2 (sFRP2) has been reported to be
involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by …
involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by …
Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia/reperfusion injury*♦
K Nakamura, S Sano, JJ Fuster, R Kikuchi… - Journal of Biological …, 2016 - ASBMB
Wnt signaling has diverse actions in cardiovascular development and disease processes.
Secreted frizzled-related protein 5 (Sfrp5) has been shown to function as an extracellular …
Secreted frizzled-related protein 5 (Sfrp5) has been shown to function as an extracellular …
Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy
P Sklepkiewicz, T Shiomi, R Kaur, J Sun… - Circulation: Heart …, 2015 - Am Heart Assoc
Background—The Wnt/β-catenin signaling pathway plays a central role during cardiac
development and has been implicated in cardiac remodeling and aging. However, the role …
development and has been implicated in cardiac remodeling and aging. However, the role …
[HTML][HTML] Multiple roles of sFRP2 in cardiac development and cardiovascular disease
YU Wu, X Liu, H Zheng, H Zhu, W Mai… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
The Wnt signaling pathway plays important roles in organ development and disease
processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling …
processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling …
Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload
Y Zou, L Pan, Y Shen, X Wang, C Huang, H Wang… - Cell death & …, 2021 - nature.com
Progressive cardiac fibrosis accelerates the development of heart failure. Here, we aimed to
explore serum Wnt5a and Wnt11 levels in hypertension patients, the roles of Wnt5a and …
explore serum Wnt5a and Wnt11 levels in hypertension patients, the roles of Wnt5a and …
FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway
J Tao, B Chen, Y Ma, Y Yang, X Li, X Ma, Z Yu… - Lipids in health and …, 2015 - Springer
Background Lately, there is accumulating evidence that the Wnt/Frizzled pathway is
reactivated after myocardial infarction, the inhibition of the pathway is beneficial since it …
reactivated after myocardial infarction, the inhibition of the pathway is beneficial since it …
[HTML][HTML] Recombinant frizzled1 protein attenuated cardiac hypertrophy after myocardial infarction via the canonical Wnt signaling pathway
J Fan, L Qiu, H Shu, B Ma, M Hagenmueller, JH Riffel… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Postinfarct cardiac hypertrophy is an independent risk factor for heart failure and sudden
death. Regression of cardiac hypertrophy has emerged as a promising strategy in the …
death. Regression of cardiac hypertrophy has emerged as a promising strategy in the …
Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a
Z Zhang, A Deb, Z Zhang, A Pachori, W He… - Journal of molecular and …, 2009 - Elsevier
We have demonstrated that mesenchymal stem cells overexpressing the survival gene Akt
can confer paracrine protection to ischemic myocytes both in vivo and in vitro through the …
can confer paracrine protection to ischemic myocytes both in vivo and in vitro through the …