The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …

Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …