Molecular mechanisms of inflammasome signaling
The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …
Molecular mechanisms involved in inflammasome activation
C Bryant, KA Fitzgerald - Trends in cell biology, 2009 - cell.com
Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …
products released from damaged or dying cells and trigger innate immunity. In most cases …
Toward targeting inflammasomes: insights into their regulation and activation
Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
Mechanisms of inflammasome activation: recent advances and novel insights
SK Vanaja, VAK Rathinam, KA Fitzgerald - Trends in cell biology, 2015 - cell.com
Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
Inflammasomes: mechanism of action, role in disease, and therapeutics
H Guo, JB Callaway, JPY Ting - Nature medicine, 2015 - nature.com
The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …
activation of caspase-1 and induce inflammation in response to infectious microbes and …
Emerging activators and regulators of inflammasomes and pyroptosis
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
Inflammasome complexes: emerging mechanisms and effector functions
VAK Rathinam, KA Fitzgerald - Cell, 2016 - cell.com
Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …
Regulation of inflammasome activation
SM Man, TD Kanneganti - Immunological reviews, 2015 - Wiley Online Library
Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …
Over the past 10 years, inflammasomes have been recognized for their roles in the host …