Highlights•IRF proteins regulate important components of inflammasome activation.•The
NLRP1b inflammasome is activated through 'functional degradation'.•NLRP6 senses …

Inflammasomes are the major mechanistic complexes that include members of the NOD-like
receptor (NLRs) or AIM2-like receptors (ALRs) families, which are affiliated with the innate …

Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …

The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …

Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

Highlights•The NLRP3, NLRC4, and pyrin inflammasomes are regulated by post-
translational modifications.•The Dhx9-NLRP9b inflammasome recognizing viral dsRNA was …

An inflammasome is a multiprotein complex that serves as a platform for caspase‐1
activation and caspase‐1‐dependent proteolytic maturation and secretion of interleukin‐1β …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …