Nonpharmacological treatment of hypercholesterolemia increases circulating endothelial progenitor cell population in adults

G Croce, G Passacquale, S Necozione… - … and Vascular Biology, 2006 - Am Heart Assoc
Hypercholesterolemia represents a major cardiovascular risk factor because of its ability to
promote and sustain proatherogenic inflammation of vascular wall. 1 A reduction of number …

[HTML][HTML] Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells

J Zhou, M Cheng, YH Liao, Y Hu, M Wu, Q Wang, B Qin… - Plos one, 2013 - journals.plos.org
Circulating endothelial progenitor cells (circEPCs) of bone marrow (BM) origin contribute to
postnatal neovascularization and represent a potential therapeutic target for ischemic …

HMG‐CoA reductase inhibitors (statins), inflammation, and endothelial progenitor cells—new mechanistic insights of atherosclerosis

A Blum - Biofactors, 2014 - Wiley Online Library
Statins have been shown to favorably affect the prognosis of patients with risk factors to
atherosclerosis—both as a primary and a secondary prevention. The beneficial effects …

Two types of circulating endothelial progenitor cells in patients receiving long term therapy by HMG-CoA reductase inhibitors

F Deschaseaux, Z Selmani, PE Falcoz, N Mersin… - European journal of …, 2007 - Elsevier
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely
used to decrease cholesterol synthesis and are well established to reduce vascular …

Does drug therapy reverse endothelial progenitor cell dysfunction in diabetes?

CV Desouza - Journal of Diabetes and its Complications, 2013 - Elsevier
Endothelial progenitor cells (EPCs) are vital for the maintenance and repair of the
endothelium. Decreased EPC number and function have been associated with increased …

Atorvastatin treatment improves endothelial function through endothelial progenitor cells mobilization in ischemic heart failure patients

E Oikonomou, G Siasos, M Zaromitidou, G Hatzis… - Atherosclerosis, 2015 - Elsevier
Objective: Endothelial function is an independent predictor of prognosis in heart failure (HF)
subjects. Statins, beyond their lipid lowering role, exert beneficial effect in patients with …

Simvastatin enhances endothelial differentiation of peripheral blood mononuclear cells in hypercholesterolemic patients and induces pro-angiogenic cytokine IL-8 …

KW Park, KK Hwang, HJ Cho, J Hur, HM Yang… - Clinica chimica acta, 2008 - Elsevier
BACKGROUND: Statins are known to have pleiotropic effects. We examined the effect and
mechanism of simvastatin therapy on EPC differentiation and pro-angiogenic cytokines in …

Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice

MR Schroeter, T Humboldt, K Schäfer… - Atherosclerosis, 2009 - Elsevier
Statins enhance incorporation of bone marrow-derived cells into experimental neointimal
lesions. However, the contribution of progenitor cells to progression of spontaneous …

The effects of HMG-CoA reductase inhibitor on vascular progenitor cells

K Takanori, O Takashi, N Daisuke, E Soichiro… - Journal of …, 2006 - Elsevier
Circulating bone marrow-derived vascular progenitor cells contribute to angiogenesis,
atherosclerosis, and the response to vascular injury. These vascular progenitor cells consist …

Synergistic effects of telmisartan and simvastatin on endothelial progenitor cells

M Steinmetz, C Brouwers, G Nickenig… - Journal of cellular …, 2010 - Wiley Online Library
Circulating endothelial progenitor cells (EPC) contribute to endothelial replenishment.
Telmisartan is an angiotensin‐receptor blocker with PPARγ‐agonistic properties. PPARγ …