The variability in metastatic patterns from diVerent primary cancers, while probably reflecting
molecular and cellular biological characteristics of both the tumour cells and the tissues to …

In the Western world one in three people will develop a malignancy, and of these two-thirds
can be expected ultimately to die of their cancer. Figures from 1980 for the European …

Metastases in bone are common, yet malignant tumours rarely arise in the skeleton. Primary
cancers in other tissues, notably the breast and colon, are common but seldom do …

Bone metastases are common complications of many cancers. Among the mechanisms that
set the scene for the development of bone metastases, several are shared by all forms of …

By M. to the skeleton, we usually mean M. due to carcinomas. M. from sarcomas, including
sarcomas of bone, are rare and terminal, and thus of little clinical interest. M. from …

Cancer is the second leading cause of death in the United States50, and it was estimated 1
that there would be 910,000 new cases here in 1985. Metastasis is one of the most serious …

The salient pathological features of metastatic bone disease were established around the
turn of the century (for references to early work, particularly in the German literature, see …

Bone metastases pose a major problem for clinicians involved in treating patients with
cancer. Although our understanding of bone formation and regulation has increased over …

Bone Metastases brings together the many recent developments that are gradually
improving the prospects for patients with secondary involvement of the skeleton in a primary …