Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

CLN Small, SA Reid-Yu, JB McPhee… - Nature …, 2013 - nature.com
Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract in which
alterations to the bacterial community contribute to disease. Adherent-invasive Escherichia …

The unique lifestyle of Crohn's disease-associated adherent-invasive Escherichia coli

CR Shaler, W Elhenawy, BK Coombes - Journal of molecular biology, 2019 - Elsevier
Escherichia coli is one of the most genetically and phenotypically diverse species of
bacteria. This remarkable diversity produces a plethora of clinical outcomes following …

Comparative genomics reveals new single-nucleotide polymorphisms that can assist in identification of adherent-invasive Escherichia coli

C Camprubí-Font, M Lopez-Siles, M Ferrer-Guixeras… - Scientific reports, 2018 - nature.com
Adherent-invasive Escherichia coli (AIEC) have been involved in Crohn's disease (CD).
Currently, AIEC are identified by time-consuming techniques based on in vitro infection of …

Understanding HostAdherentInvasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies

A Agus, S Massier, A Darfeuille-Michaud… - BioMed research …, 2014 - Wiley Online Library
A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved
with the host in a symbiotic relationship and some of them have developed strategies to …

Pathogenic Role of Associated AdherentInvasive Escherichia coli in Crohn's Disease

G Mazzarella, A Perna, A Marano… - Journal of cellular …, 2017 - Wiley Online Library
Several lines of evidence suggest that adherentinvasive Escherichia coli (AIEC) strains
play an important role in Crohn's disease (CD). The objective of this study was to investigate …

Host-specific adaptive diversification of Crohn's disease-associated adherent-invasive Escherichia coli

W Elhenawy, CN Tsai, BK Coombes - Cell Host & Microbe, 2019 - cell.com
Crohn's disease (CD) is an inflammatory bowel disease influenced by bacteria. Adherent-
invasive E. coli (AIEC) is associated with CD, yet the adaptations facilitating AIEC gut …

Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease

A Darfeuille-Michaud - International Journal of Medical Microbiology, 2002 - Elsevier
Crohn's disease (CD) is an inflammatory bowel disease (IBD) of unknown aetiology.
Genetically engineered rodent models showed that IBDs are immunologically mediated and …

Acute infectious gastroenteritis potentiates a Crohn's disease pathobiont to fuel ongoing inflammation in the post-infectious period

CL Small, L Xing, JB McPhee, HT Law… - PLoS …, 2016 - journals.plos.org
Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to
foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into …

Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli

CL O'Brien, MA Bringer, KE Holt, DM Gordon… - Gut, 2017 - gut.bmj.com
Objective Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial
trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays …

Inflammation-associated Adherent-invasive Escherichia coli Are Enriched in Pathways for Use of Propanediol and Iron and M-cell Translocation

B Dogan, H Suzuki, D Herlekar… - Inflammatory bowel …, 2014 - academic.oup.com
Background Perturbations of the intestinal microbiome, termed dysbiosis, are linked to
intestinal inflammation. Isolation of adherent-invasive Escherichia coli (AIEC) from intestines …