Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage

SC Nardelli, JPC da Cunha, MCM Motta, S Schenkman - Chromosoma, 2009 - Springer
Histones of trypanosomes are quite divergent when compared to histones of most
eukaryotes. Nevertheless, the histone H4 of Trypanosoma cruzi, the protozoan that causes …

[HTML][HTML] Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi

TCP Ramos, VS Nunes, SC Nardelli… - Molecular and …, 2015 - Elsevier
The histone H4 from Trypanosomatids diverged from other eukaryotes in the N-terminus, a
region that undergoes post-translation modifications involved in the control of gene …

Post-translational modifications of Trypanosoma cruzi histone H4

JPC da Cunha, ES Nakayasu, IC de Almeida… - Molecular and …, 2006 - Elsevier
Histone tails provide sites for a variety of post-translational modifications implicated in the
control of gene expression and chromatin assembly. As both histones and control of gene …

Histone H1 of Trypanosoma cruzi Is Concentrated in the Nucleolus Region and Disperses upon Phosphorylation during Progression to Mitosis

LM Gutiyama, JPC da Cunha, S Schenkman - Eukaryotic cell, 2008 - Am Soc Microbiol
Phosphorylation of histone H1 is intimately related to the cell cycle progression in higher
eukaryotes, reaching maximum levels during mitosis. We have previously shown that in the …

Histone H1 is phosphorylated in non-replicating and infective forms of Trypanosoma cruzi

RM Porto, R Amino, MCQ Elias, M Faria… - Molecular and …, 2002 - Elsevier
The nuclear structure changes during the differentiation from growing to infective stages of
Trypanosoma cruzi. As histone modifications have been correlated with structural and …

Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi

TCL de Jesus, VS Nunes, MC Lopes… - Journal of proteome …, 2016 - ACS Publications
Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes
and undergo several post-translational modifications, which are important for the control of …

Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei

TN Siegel, T Kawahara, JA DeGrasse… - Molecular …, 2008 - Wiley Online Library
Post‐translational histone modifications have been studied intensively in several
eukaryotes. It has been proposed that these modifications constitute a 'histone code'that …

Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle

JPC da Cunha, ES Nakayasu, MC Elias… - Molecular and …, 2005 - Elsevier
Histone H1 of most eukaryotes is phosphorylated during the cell cycle progression and
seems to play a role in the regulation of chromatin structure, affecting replication and …

H 1 histone and histone variants in Trypanosoma cruzi

GC Toro, N Galanti - Experimental cell research, 1988 - Elsevier
Trypanosoma cruzi chromatin is not condensed in chromosomes during mitosis. In previous
studies a characteristic H 1 was not found in SDS or in acid-urea-PAGE. Consequently, it …

Histone modifications in Trypanosoma brucei

V Mandava, JP Fernandez, H Deng, CJ Janzen… - Molecular and …, 2007 - Elsevier
Several biological processes in Trypanosoma brucei are affected by chromatin structure,
including gene expression, cell cycle regulation, and life-cycle stage differentiation. In …