As an intracellular parasite, Trypanosoma cruzi is exposed to reactive oxygen species. The
study of the proteins involved in the hydroperoxide detoxification cascade, tryparedoxin …

Trypanosoma cruzi is exposed to oxidative stresses during its life cycle, and amongst the
strategies employed by this parasite to deal with these situations sits a peculiar …

Trypanosoma cruzi antioxidant enzymes are among the factors that guarantee parasite
survival and maintain infection, enabling T. cruzi to cope with oxidative stress. Herein, the …

Different stages of Trypanosoma cruzi are able to metabolize low concentrations of H 2 O 2.
Trypomastigotes showed a higher initial rate per mg protein than amastigotes or …

Trypanosoma cruzi's antioxidant system is unique and relevant to the parasite. In this study,
quantitative assays were performed to determine cytosolic and mitochondrial tryparedoxin …

Ascorbate peroxidases (APX) are class I heme-containing enzymes that convert hydrogen
peroxide into water molecules. The gene encoding APX has been characterized in 11 …

Cytosolic and mitochondrial Trypanosoma cruzi tryparedoxin peroxidases belong to the
family of 2-Cys peroxiredoxins. These enzymes play an essential role as antioxidants by …

The American trypanosome Trypanosoma cruzi is exposed to toxic oxygen metabolites that
are generated by drug metabolism and immune responses in addition to those produced by …

Significance: Chagas disease (CD) affects several million people in Latin America and is
spreading beyond its classical boundaries due to the migration of infected host and insect …

Trypanosoma cruzi is the etiologic agent of Chagas' disease, an infection that affects several
million people in Latin America. With no immediate prospect of a vaccine and problems …