Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

To start to understand the role of chromatin structure in regulating transcription in
trypanosomes, we analyzed covalent modifications on the four core histones of …

Nuclear DNA is wrapped around histones. Vigorous research over the past decade has
established a central role for histone post-translational modification in controlling the DNA …

The histones are responsible for packaging and regulating access to eukaryotic genomes.
Trypanosomatids are flagellated protists that diverged early from the eukaryotic lineage and …

Background Genomic organization and gene expression regulation in trypanosomes are
remarkable because protein-coding genes are organized into codirectional gene clusters …

Epigenetic regulation is important in many facets of eukaryotic biology. Recent work has
suggested that the basic mechanisms underlying epigenetic regulation extend to eukaryotic …

Trypanosomes are ancient eukaryotic parasites in which the protein-coding genes,
organized in large polycistronic clusters on both strands, are transcribed from as yet …

Protein acetylation is a post-translational modification regulating diverse cellular processes.
By using proteomic approaches, we identified N-terminal and ε-lysine acetylated proteins in …

The Trypanosomatidae family includes pathogenic species of medical and veterinary
interest. Chagas disease is endemic in Latin America, and about 8 million people are …

Trypanosomatids are parasites of worldwide distribution with relevant importance in human
and veterinary health, which inhabit invertebrate and vertebrate hosts, such that they are …