Trypanosoma brucei developed a sophisticated life cycle to adapt to different host
environments. Although developmental differentiation of T. brucei has been the topic of …

Some inroads have been made into characterizing histone variants and post translational
modifications of histones in Trypanosoma brucei. Histone variant H2BV lysine 129 is …

Post-translational modifications (PTMs) of histone tails play a key role in epigenetic
regulation of gene expression in a range of organisms from yeast to human; however, little is …

Trypanosoma cruzi, the causative agent of Chagas disease, has evolved particular
mechanisms of gene regulation. Gene expression is regulated firstly at post-transcriptional …

Histone post-translational modifications (PTMs) such as acetylation and methylation are
known to affect chromatin higher order structures. Primary targets of these modifications …

Trypanosoma cruzi, the protozoan that causes Chagas disease, possesses a complex life
cycle involving different developmental stages. Experimental conditions for two‐dimensional …

Trypanosoma cruzi is the etiological agent of Chagas. Although the nuclear chromatin of this
parasite is organized in the form of nucleosome filaments, its chromatin is physically and …

Post-translational modifications (PTMs) of histones regulate almost all facets of DNA
metabolism in eukaryotes, such as replication, repair, transcription and chromatin …

Lysine succinylation is a new posttranslational modification identified in histone proteins of
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa. However …

Reversible protein acetylation is established as a modification of major regulatory
significance. In particular, histone acetylation regulates access to genetic information in …