The nucleus of the human pathogen Trypanosoma brucei not only has unusual
chromosomal composition, characterised by the presence of megabase, intermediate and …

Trypanosoma cruzi alternates between replicative and nonreplicative life forms,
accompanied by a shift in global transcription levels and by changes in the nuclear …

Reversible protein acetylation is established as a modification of major regulatory
significance. In particular, histone acetylation regulates access to genetic information in …

In the protozoan parasite Trypanosoma cruzi, as in other trypanosomatids, transcription of
protein coding genes occurs in a constitutive fashion, producing large polycistronic …

Arginine methylation is a common posttranslational modification with reported functions in
transcription, RNA processing and translation, and DNA repair. Trypanosomes encode five …

Trypanosoma brucei is a protozoan flagellate that is transmitted by tsetse flies into the
mammalian bloodstream. The parasite has a huge impact on human health both directly by …

Chromatin dynamics can regulate all DNA-dependent processes. Access to DNA within
chromatin is orchestrated mainly by histones and their posttranslational modifications …

The Trypanosomatidae family is characterized by flagellated protozoa presenting a
kinetoplast. Several genera of this family contain species that are pathogenic to man and …

The completion of the genome sequence of Trypanosoma cruzi has been followed by
several studies of protein expression, with the long‐term aim to obtain a complete picture of …

The parasites Leishmania spp., Trypanosoma brucei, and Trypanosoma cruzi are the
trypanosomatid protozoa that cause the deadly human diseases leishmaniasis, African …