Hepatocellular carcinoma (HCC) is mostly triggered by environmental and life-style factors
and may involve epigenetic aberrations. However, a comprehensive documentation of the …

DNA methylation is a key transcription regulator, whose aberration was ubiquitous and
important in most cancers including hepatocellular carcinoma (HCC). Whole-genome …

Cancer develops through the accumulation of genetic and epigenetic aberrations. To
identify sequential molecular alterations that occur during the development of hepatocellular …

Background Hepatocellular carcinoma (HCC) is one of the most common cancers and
frequently presents with an advanced disease at diagnosis. There is only limited knowledge …

Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We
aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular …

Background: Methylation plays a significant role in the etiology and pathogenesis of
hepatocellular carcinoma (HCC). The aim of the present study is to identify aberrantly …

Disruption of epigenetic mechanisms has been intimately linked to the etiology of human
cancer. Understanding how these epigenetic mechanisms (including DNA methylation …

Background & Aims Epigenetic silencing of tumor suppressor genes contributes to the
pathogenesis of hepatocellular carcinoma (HCC). To identify clinically relevant tumor …

Background & Aims A causal link has recently been established between epigenetic
alterations and hepatocarcinogenesis, indicating that epigenetic inhibition may have …

Background Alcohol is a well-known risk factor for hepatocellular carcinoma (HCC), but the
mechanisms underlying the alcohol-related hepatocarcinogenesis are still poorly …