Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Zinc is required for the regulation of proliferation, metabolism, and cell signaling. It is an
intracellular second messenger, and the cellular level of ionic, mobile zinc is strictly …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …

Abstract Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT)
family transporters, are found in all aspects of life. Increasing evidence has clarified the …

Zinc is an important trace metal in immune systems, and zinc transporters are involved in
many immune responses. Recent advances have revealed the structural and biochemical …

Zinc transporter 1 (ZNT1) is the only zinc transporter predominantly located on the plasma
membrane, where it plays a pivotal role exporting cytosolic zinc to the extracellular space …

Zinc (Zn) is a vital element. It plays indispensable roles in multifarious cellular processes,
affecting the expression and activity of a variety of molecules, including transcription factors …

Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …