ABSTRACT DNA methylation can affect tissue-specific gene transcription in ways that are
difficult to discern from studies focused on genome-wide analyses of differentially …

Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive …

DNA methylation in mammals is highly dynamic during germ cell and preimplantation
development but is relatively static during the development of somatic tissues. 5 …

Epigenetic mechanisms such as microRNA and histone modification are crucially
responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA …

Differential DNA methylation exists in the epigenome of end-stage failing human hearts but
whether it contributes to disease progression is presently unknown. Here, we report that …

The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …

Rapidly advancing high-throughput sequencing technology is now bringing attention to
many basic biological aspects of the human genome. DNA methylation refers to the …

DNA methylation, an epigenetic mechanism is claimed to play essential roles in
development, aging and disease over the past few decades. Cytosines (C) were known to …

Although high levels of 5-hydroxymethylcytosine (5hmC) accumulate in mammalian
neurons, our knowledge of its roles in terminal differentiation or as an intermediate in active …

DNA methylation occurs at cytosines, predominantly in the CpG dinucleotide context and is
a key epigenetic regulator of embryogenesis and stem-cell differentiation in mammals. The …