The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
LE Dorn, L Lasman, J Chen, X Xu, TJ Hund… - Circulation, 2019 - Am Heart Assoc
Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
m6A-mRNA methylation regulates cardiac gene expression and cellular growth
V Kmietczyk, E Riechert, L Kalinski… - Life science …, 2019 - life-science-alliance.org
Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications,
which can affect their activity, localization, and stability. The most prevalent internal …
which can affect their activity, localization, and stability. The most prevalent internal …
mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification
R Kumari, P Ranjan, ZG Suleiman… - Cardiovascular …, 2022 - academic.oup.com
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …
RNA epitranscriptomic modification and controls multiple cellular functions during …
N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant and prevalent epigenetic
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …
[HTML][HTML] METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury
L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …
to various pathophysiological processes. Although the benefit of regular exercise on the …
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury
R Gong, X Wang, H Li, S Liu, Z Jiang, Y Zhao… - Pharmacological …, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A), one of the important epigenitic modifications, is
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases
A Paramasivam, J Vijayashree Priyadharsini… - Hypertension …, 2020 - nature.com
To the Editor: Epitranscriptomics is an emerging field of biology, in which post-transcriptional
modifications of RNA, as a novel mechanism discovered recently, are suggested to be a vital …
modifications of RNA, as a novel mechanism discovered recently, are suggested to be a vital …
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation
T Berulava, E Buchholz, V Elerdashvili… - European journal of …, 2020 - Wiley Online Library
Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …
[HTML][HTML] Emerging roles and mechanism of m6A methylation in cardiometabolic diseases
Z Xu, B Lv, Y Qin, B Zhang - Cells, 2022 - mdpi.com
Cardiometabolic diseases (CMDs) are currently the leading cause of death and disability
worldwide, and their underlying regulatory mechanisms remain largely unknown. N6 …
worldwide, and their underlying regulatory mechanisms remain largely unknown. N6 …
[HTML][HTML] Changes in N6-methyladenosine modification modulate diabetic cardiomyopathy by reducing myocardial fibrosis and myocyte hypertrophy
W Ju, K Liu, S Ouyang, Z Liu, F He… - Frontiers in Cell and …, 2021 - frontiersin.org
In this study, we aimed to systematically profile global RNA N6-methyladenosine (m6A)
modification patterns in a mouse model of diabetic cardiomyopathy (DCM). Patterns of m6A …
modification patterns in a mouse model of diabetic cardiomyopathy (DCM). Patterns of m6A …