Characterization of unconventional kinetochore kinases KKT10 and KKT19 in Trypanosoma brucei

M Ishii, B Akiyoshi - Journal of cell science, 2020 - journals.biologists.com
The kinetochore is a macromolecular protein complex that drives chromosome segregation
in eukaryotes. Unlike most eukaryotes that have canonical kinetochore proteins …

Identification of four unconventional kinetoplastid kinetochore proteins KKT22–25 in Trypanosoma brucei

OO Nerusheva, P Ludzia, B Akiyoshi - Open biology, 2019 - royalsocietypublishing.org
The kinetochore is a multi-protein complex that drives chromosome segregation in
eukaryotes. It assembles onto centromere DNA and interacts with spindle microtubules …

Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei

M Ishii, P Ludzia, G Marcianò, W Allen… - Molecular biology of …, 2022 - Am Soc Cell Biol
Chromosome segregation requires assembly of the macromolecular kinetochore complex
onto centromeric DNA. While most eukaryotes have canonical kinetochore proteins that are …

Kinetoplastid kinetochore proteins KKT14–KKT15 are divergent Bub1/BubR1–Bub3 proteins

D Ballmer, W Carter, JJE van Hooff… - Open …, 2024 - royalsocietypublishing.org
Faithful transmission of genetic material is crucial for the survival of all organisms. In many
eukaryotes, a feedback control mechanism called the spindle checkpoint ensures …

[HTML][HTML] Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein

P Ludzia, ED Lowe, G Marciano, S Mohammed… - Structure, 2021 - cell.com
The kinetochore is the macromolecular machinery that drives chromosome segregation by
interacting with spindle microtubules. Kinetoplastids (such as Trypanosoma brucei), a group …

Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains

G Marciano, M Ishii, OO Nerusheva, B Akiyoshi - Journal of Cell Biology, 2021 - rupress.org
The kinetochore is the macromolecular protein complex that assembles onto centromeric
DNA and binds spindle microtubules. Evolutionarily divergent kinetoplastids have an …

[HTML][HTML] Discovery of unconventional kinetochores in kinetoplastids

B Akiyoshi, K Gull - Cell, 2014 - cell.com
The kinetochore is the macromolecular protein complex that directs chromosome
segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of …

A CLK1-KKT2 signaling pathway regulating kinetochore assembly in Trypanosoma brucei

M Saldivia, AJM Wollman, JBT Carnielli, NG Jones… - MBio, 2021 - Am Soc Microbiol
During mitosis, eukaryotic cells must duplicate and separate their chromosomes in a precise
and timely manner. The apparatus responsible for this is the kinetochore, which is a large …

The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip–coupling protein

A Llauró, H Hayashi, ME Bailey, A Wilson… - Journal of Cell …, 2018 - rupress.org
Kinetochores are multiprotein machines that drive chromosome segregation by maintaining
persistent, load-bearing linkages between chromosomes and dynamic microtubule tips …

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes

S D'Archivio, B Wickstead - Journal of Cell Biology, 2017 - rupress.org
Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic
spindle to ensure proper segregation. The model for kinetochore assembly is conserved …