Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that
express GABA. However, little is known about how sleep neuron function is determined and …

Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active
neurons are under the control of homeostatic mechanisms that determine sleep need …

Background Sleep is an essential behavior that is found in all animals that have a nervous
system. Neural activity is thought to control sleep, but little is known about the identity and …

The genetic basis of sleep regulation remains poorly understood. In C. elegans, cellular
stress induces sleep through epidermal growth factor (EGF)-dependent activation of the EGF …

The past 10 years have seen new approaches to elucidating genetic pathways regulating
sleep. The emerging theme is that sleep-like states are conserved in evolution, with similar …

In response to environments that cause cellular stress, animals engage in sleep behavior
that facilitates recovery from the stress. In Caenorhabditis elegans, stress-induced sleep …

Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In
Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates …

Sleep is crucial for survival and well-being. This behavioral and physiological state has
been studied in all major genetically accessible model animals, including rodents, fish, flies …

Prolonged wakefulness leads to an increased pressure for sleep, but how this homeostatic
drive is generated and subsequently persists is unclear. Here, from a neural circuit screen in …

How the circadian clock regulates the timing of sleep is poorly understood. Here, we identify
a Drosophila mutant, wide awake (wake), that exhibits a marked delay in sleep onset at …