Sleep is a complex and plastic behavior regulated by multiple brain regions and influenced
by numerous internal and external stimuli. Thus, to fully uncover the function (s) of sleep …

Sleep is under homeostatic control, but the mechanisms that sense sleep need and correct
sleep deficits remain unknown. Here, we report that sleep-promoting neurons with …

Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold,
and rapid reversibility. Understanding how these properties are encoded by a neuronal …

Sleep is an essential and phylogenetically conserved behavioral state, but it remains
unclear to what extent genes identified in invertebrates also regulate vertebrate sleep …

How the homeostatic drive for sleep accumulates over time and is released remains poorly
understood. In Drosophila, we previously identified the R5 ellipsoid body (EB) neurons as …

Major questions on the biology of sleep include the following: what are the molecular
functions of sleep; why can wakefulness only be sustained for defined periods before there …

INTRODUCTION Global brain states such as sleep and wakefulness involve
reconfigurations of neural circuit activity across the entire nervous system. Yet it is not …

Highlights•Potassium channel dynamics control excitability of sleep-promoting neurons in
flies.•The Drosophila ellipsoid body and dorsal fan-shaped body interact to drive sleep …

Enhanced sleep in response to cellular stress is a conserved adaptive behavior across
multiple species, but the mechanism of this process is poorly understood. Drosophila …

Highlights▶ Caenorhabditis elegans sleep occurs during lethargus, a larval stage transition
period.▶ Sensory gating during C. elegans sleep occurs in sensory neurons.▶ C. elegans …